The CLDN7 Antibody from MyBioSource.com is a Rabbit Polyclonal antibody to Claudin 7, and CLDN7. This antibody recognizes Human, Mouse, and Rat antigen. The CLDN7 Antibody has been validated for the following applications: ELISA, Immunohistochemistry, and Western Blot.
Description
Description: This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. Differential expression of this gene has been observed in different types of malignancies, including breast cancer, ovarian cancer, hepatocellular carcinomas, urinary tumors, prostate cancer, lung cancer, head and neck cancers, thyroid carcinomas, etc. Alternatively spliced transcript variants encoding different isoforms have been found.[provided by RefSeq, May 2010].
Function: Plays a major role in tight junction-specific obliteration of the intercellular space.
Subunit Structure: Directly interacts with TJP1/ZO-1, TJP2/ZO-2 and TJP3/ZO-3 (By similarity). The phosphorylated form interacts with EPCAM (PubMed:16054130). Does not interact with CD81 (PubMed:20375010).
Post-translational Modifications: Phosphorylated.
Similarity: Belongs to the claudin family